software for the analysis of false discovery rates in high-throughput screening experiments

SmartTail offers a novel approach to high-throughput testing, providing accurate and efficient estimates of false discovery rates and related quantities. SmartTail uses Extreme Value Statistics as a powerful tool for the analysis of tails of the distribution of p-values from high-throughput screening experiments. SmartTail can be used to correct theoretical p-values and compare different pre-processing methods.

SmartTail GUI

Required OS:

  1. Install the 64-bit version of MATLAB R2017b Compiler Runtime (MCR): MCR Installer v9.3.

  2. Download SmartTail and datasets used in Rootzén and Zholud (2015). A short introduction on how to use SmartTail is given in supplementary materials.

You may also visit our GitHub repository.


Rootzén, H. and Zholud, D. (2015). Efficient estimation of the number of false positives in high-throughput screening, Biometrika, Vol. 102, No. 3, pp. 695-704.

(c) 2019 Dmitrii Zholud